The COMAND APS multimedia system with CD/DVD drive is included as standard with the SLS. It combines navigation, audio and telephone functions and shows all information on a central 7-inch colour display. The system is operated using a controller (ergonomically located within easy reach in front of the centre console) or buttons on the steering wheel. With the LINGUATRONIC voice-operated control system COMAND APS can even respond to your voice.

The pan-European navigation system features a 40 GB hard drive for storing navigation data. This leads to a significantly quicker route calculation.

The radio, with integrated CD/DVD player, features an FM/MW/SW/LW dual tuner with automatic station search, RDS function, a 4 x 25 W amplifier and a total of six speakers. COMAND APS also contains a music server with 4 GB of memory for MP3 files which can store up to 1000 music tracks. An integrated DVD changer for 6 DVDs is also available as an optional extra. Below the DVD slot, the device includes an adapter for use with different PC memory cards for playback of music files. External audio devices (such as an iPod®) can be connected to the COMAND APS via the Media Interface (optional extra).

The optional new sound system has been specially developed for the SLS by Mercedes-Benz and AMG, together with Danish audio specialists Bang & Olufsen. The Bang & Olufsen BeoSound AMG with Dolby Digital 5.1 high-end surround sound system provides an exclusive music experience of the highest standard. The basis for this is not just the 1000 W ICE power amplifier and 11 high-powered speakers, but also the precise distribution of the music signals controlled by the sound processor. Other highlights include the two 250 W subwoofers integrated in the rear shelf and the 50 W illuminated tweeters on the instrument panel.